Which of the following statements would best characterize a high positive predictive value but a low negative predictive value for this screening test?

As part of a screening program for prostate cancer, men at a senior citizens’ center are having their blood levels of prostate-specific antigen (PSA) measured.Which of the following statements would best characterize a high positive predictive value but a low negative predictive value for this screening test?

Answers:

A. All of the men who had low PSA levels were cancer-free; several men who had high levels also remained free of prostate cancer.

B.Men who had low PSA levels also displayed false-positive results for prostate cancer; men with high levels were often falsely diagnosed with prostate cancer.

C. The test displayed low sensitivity but high specificity.

D. All of the men who had high PSA levels developed prostate cancer; several men who had low PSA levels also developed prostate cancer.

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