Case Study- Clozaril

A 35 year old African American female who has been hospitalized for the 4th time in 2 months after another psychotic episode including paranoid delusions and both auditory and visual hallucinations. She was diagnosed with paranoid schizophrenia (ICD 10 F20.0) in her early 20\’s. She lives in a group home and attends partial day program at a local community health center.

She has been on multiple 2nd generation antipsychotics and several 1st generation antipsychotics; none have shown to be effective. During a team meeting, it was determined that she will be started on CLOZAPINE (CLOZARIL).

Questions:

1) Why is clozapine (clozaril) a good choice for this patient? Under what circumstances should clozaril generally be considered?

  1. 2) What baseline laboratory tests, diagnostic tests, and monitoring should be completed with clozaril treatment? What is the rationale?
  2. 3) What is the dosing for clozapine (clozaril)?
  3. 4) What is the prescriber site (URL and title) for those who prescribe clozapine (clozaril)? Why are prescribers required to register?
  4. 5) Describe the ongoing monitoring that is required for a patient taking clozapine (clozaril)? Identify the rationale for this monitoring.
  5. 6) What are the side effects of clozapine (clozaril) that are monitored?
  7. Provide 2 double spaced pages NOT including the reference page. Include 3 references that are peer-reviewed, evidenced-based articles.

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